Cadherin-23 may be dynamic in hair bundles of the model sea anemone Nematostella vectensis.

Cadherin-23 may be dynamic in hair bundles of the model sea anemone Nematostella vectensis.

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Cadherin 23 (CDH23), a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear.A homolog of CDH23 occurs in hair bundles of sea anemones.Anemone hair bundles are located read more on the tentacles where they detect the swimming movements of nearby prey.The anemone CDH23 is predicted to be a large polypeptide featuring a short exoplasmic C-terminal domain that is unique to sea anemones.

Experimentally masking this domain with antibodies or mimicking this domain with free peptide rapidly disrupts mechanotransduction and morphology of anemone hair bundles.The loss of normal morphology is teal horse blanket accompanied, or followed by a decrease in F-actin in stereocilia of the hair bundles.These effects were observed at very low concentrations of the reagents, 0.1-10 nM, and within minutes of exposure.

The results presented herein suggest that: (1) the interaction between CDH23 and molecular partners on stereocilia of hair bundles is dynamic and; (2) the interaction is crucial for normal mechanotransduction and morphology of hair bundles.